Lock In by John Scalzi
Mystery and science fiction make a great pairing and Lock In by John Scalzi does it well. It's a police procedural set in a future where a portion of the population has been affected by Haden's syndrome, leaving some "locked in, " awake and aware, but unable to move or respond without computer/mechanical help.
I find a read more sci-fi every year and really enjoy it. Lock In is light on the sci-fi side. It's near future and the tech is obviously more advance, allowing human brains to connect with "threeps" (named after C-3PO), the robots that allow locked Haden victims to move, talk, interact with the real world and with the Agora, a virtual world that allows Hadens to communicate with each other, to have their own "spaces" and communal areas. But it all feels distinctly possible and here. It's not space ships and AI robots. There are Hadens who never use a threep, who basically live and work in...